Farrell a doubt for Scotland

Margaret Thatcher was Prime Minister the last time Scotland beat England at Twickenham

Here is our preview pack, which includes the team news, quotes from coaches, key facts, the latest Sky Bet odds and the thoughts of our Steve Bramley to help you with your bets.

Billy Vunipola has missed all of England's Six Nations campaign with knee ligament damage but he proved his fitness by lasting 72 minutes in Saracens' 35-27 win over Newcastle Falcons last weekend and is set to be used as an impact substitute on Saturday.

They have scored seven tries in three games without having yet played Italy, while England have touched down nine times including six against the Azzurri at Twickenham.

Jones, who has also brought back scrum-half Ben Youngs and wing Jack Nowell, eventually decided caution was the wiser play with Billy Vunipola and named him on a super-powered bench along with Anthony Watson who will make his first England appearance of the season.

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Scotland have made one change to their starting line-up with flanker Hamish Watson, who replaced John Hardie off the bench against Wales a fortnight ago, promoted. Vunipola injured his knee in November and made his club return last Sunday.

England: 15 Mike Brown, 14 Jack Nowell, 13 Jonathan Joseph, 12 Owen Farrell, 11 Elliot Daly, 10 George Ford, 9 Ben Youngs; 1 Joe Marler, 2 Dylan Hartley (c), 3 Dan Cole, 4 Joe Launchbury, 5 Courtney Lawes, 6 Maro Itoje, 7 James Haskell, 8 Nathan Hughes.

Scotland: Hogg (Glasgow); Seymour (Glasgow), Jones (Stormers), Dunbar (Glasgow), Visser (Harlequins), Russell (Glasgow), Price (Glasgow); Reid (Glasgow), Brown (Glasgow), Fagerson (Glasgow), R Gray (Toulouse), J Gray (Glasgow), Barclay (Scarlets, capt), Watson (Edinburgh), Wilson (Glasgow).

South African-born Cornell du Preez is on the bench for the first time.

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When it was pointed out that his answers could be construed as ambiguous, Jones added: "Yeah, but I think he'll be all right, is that okay?"

"[Billy's] always in with a chance, he's one of our best players, but he's not ready to start yet", he explained. They are brimming with confidence but can they halt the English juggernaut?

"I didn't see what happened but he'll be completely fine".

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