Amgen's Repatha Results Not Good Enough For The Street

Patients treated with injectable drug Repatha saw levels of ‘bad’ LDL cholesterol drop by 60 per cent more than if they had been taking statins alone

It is why millions of people take drugs called statins to reduce the amount of bad cholesterol. In the FOURIER study, Repatha dropped LDL cholesterol in patients by 59% compared to placebo.

Results from the long-awaited Fourier trial, created to test Amgen's Repatha as a tool to cut cardiovascular risks, showed that the drug scythed heart attack risks by 27% over the course of the study, which followed patients for an average of two years.

"However, the trial was stopped early after only 2.2 years of average follow-up and therefore it is hard to be certain about the actual extent of the longer term benefit, including the impact on dying from heart disease, as well as longer term safety". At one year, there was a 16% relative risk reduction for the combination of cardiovascular death, heart attack and stroke. There were no new safety concerns identified in the trial, either.

You can now use Alexa in the Amazon app on your iPhone
Alexa will begin rolling out to iOS devices today, and should be available to everyone in the USA be next week. However, we doubt that you'll have access to Echo-exclusive promotions that Amazon runs from time to time.

The simplest explanation is that the markets wanted to see an even greater cardiovascular risk reduction. This raises the concern that insurers might not be willing to remove numerous restrictions that they have placed on accessing Repatha unless Amgen is willing to give in on pricing.

The cost varies, but it is thought to cost the UK's NHS about £2,000 per year per patient where it is already being given to people who do not respond to statins. Investors were particularly disappointed that the study did not show the drug reduced deaths, analysts said.

"With this trial, we now have definitive data that by adding evolocumab to a background of statin therapy, we can significantly improve cardiovascular outcomes and do so safely", said Marc S. Sabatine, MD, the Lewis Dexter, MD, Distinguished Chair in Cardiovascular Medicine at Brigham and Women's Hospital in Boston, chair of the Thrombolysis in Myocardial Infarction (TIMI) study group and the study's lead author. That's believed by many to make it a more attractive option than now available PCSK9 inhibitors, which require monthly or bi-weekly injections. However, the cholesterol lowering effect tended to diminish over time in some patients and bococizumab did not reduce cardiovascular event rates among those with LDL levels lower than 100 mg/dL. Traders believed that Amgen's positive announcement would increase the chances of bempedoic acid winning FDA approval by 2020, once its Phase 3 safety and efficacy studies are completed. Regeneron's stock fell by more than 4% while Sanofi is down by just over 1%, most likely because Sanofi has a more diversified product portfolio.

Trump Admin Threatens To Withdraw From UN Human Rights Council
The travel offer came from the State Department, and "after editorial consultation, McPike accepted the seat", he said. Tillerson's aircraft for the trip to Asia, where the secretary of state began his diplomatic visit in Japan Wednesday.

This last result is something insurers care about - preventing costly health care. These two companies are also funding an expensive long-term cardiovascular study called ODYSSEY OUTCOMES that is expected to wrap up later this year. Amgen announced in February that the drug was a success, but details of the research were not released until Friday.

Amgen Inc ( AMGN ) said that the 27,564-patient Repatha or evolocumab cardiovascular outcomes study, FOURIER, established for the first time that maximally reducing low-density lipoprotein cholesterol (LDL-C) levels with Repatha, beyond what is possible with the current best therapy alone, leads to a further reduction in major cardiovascular events, including heart attacks, strokes and coronary revascularizations.

If Amgen's data don't move the needle and Repatha remains a blockbuster interrupted, there could be a chilling effect on cardiovascular R&D in the drug industry. Unfortunately, it is still too early to know the answer to that question.

Angry India proof that Australia are doing well
Both teams needs to move on from Bangalore and focus should get back on to the series because priority here is cricket. To say he's worse than somebody else is unfair as everyone does it, and some blokes do it differently to Kohli.

The global team, which includes researchers from Imperial College London, says the drug could provide added benefit to patients already taking statins by further reducing the levels of low-density lipoprotein (LDL) cholesterol in their blood.


Related News

  • Cheltenham: Gold Cup day

    Cheltenham: Gold Cup day

    With her step father as her trainer and her mother part-owner of the horse she is riding, it is very much a family enterprise. The grand Gold Cup Chase which is the biggest event of the festival is set to be won by Djakadam and Rupert Walsh.
    BBC film crew pummelled by falling rocks from erupting volcano

    BBC film crew pummelled by falling rocks from erupting volcano

    The frightening ordeal was caught on camera by a BBC film crew, and science reporter Rebecca Morelle described the chaos. Mt Etna in Sicily is one of the world's most active volcanoes, with a major eruption occurring once every few years.

    Charges Announced in Massive Cyber Intrusion Case

    After announcing the indictments US will put out another official request for their extradition, he said. The hack in question was initiated in 2014 and compromised over 500 million accounts .
  • City knocked out of Champions League

    City knocked out of Champions League

    City's attacks were few and far between and those they did piece together fizzled out before they reached the box. The draw for Champions League quarterfinals will be held in Nyon's UEFA headquarters on Friday.
    Trump to reopen review of USA  fuel efficiency standards

    Trump to reopen review of USA fuel efficiency standards

    Trump said that he would engage in deregulation while also renegotiating free trade agreements in order to meet these objectives. Auto companies agreed to the tighter standards in 2011 that would almost double the fleet's efficiency to 54.5 miles per gallon.
    Tarver resigns; Durham appointed acting US Attorney for Southern District of Georgia

    Tarver resigns; Durham appointed acting US Attorney for Southern District of Georgia

    As anyone who has ever lost anyone to heroin addiction can attest, marijuana is absolutely in no way "slightly less very bad ". But if Sessions wants to educate Americans on "the bad truth" about drugs, he should probably start with himself.
  • Russian Federation  runs up cyber score against USA  with Yahoo, election hacks

    Russian Federation runs up cyber score against USA with Yahoo, election hacks

    Haley has been tougher on Russia than Trump, who has expressed hope for better relations with Russian President Vladimir Putin. Indictment links Russia's FSB to massive hacking operation that compromised 500 million accounts. .

    Former Vols coach Cuonzo Martin offered Mizzou job according to reports

    Cuonzo Martin is on the move again, and the former Missouri State men's basketball coach may be headed back to the Show-Me State. His Golden Bears were bounced from the first round of the NIT Tuesday night after being upset at home by Cal State Bakersfield.

    Business gives energy plan pass mark but governance concerns remain

    While environmental and renewable energy groups have welcomed the increased funding for renewable energy. Labor energy spokesman Mark Butler said it was a "genuine crisis" requiring national leadership.
  • Wenger admits that Arsenal 'cannot waste points'

    Wenger admits that Arsenal 'cannot waste points'

    You try to do as well as you can. " I have nothing to say about that anymore ". "I have talked enough about that". To win the FA Cup, though, Arsenal have to get past Manchester City in a tough semifinal at Wembley next month.
    Northwestern Wins Undeservedly Thanks To Huge Vandy Boner

    Northwestern Wins Undeservedly Thanks To Huge Vandy Boner

    However, it's the big moments near the end that most remember, and his unnecessary foul here is going to be long-remembered. Fisher-Davis immediately looked up to the scoreboard after fouling McIntosh and realized his mistake.
    Trump Ally: President Was Likely Wrong On Obama Wiretapping Claim

    Trump Ally: President Was Likely Wrong On Obama Wiretapping Claim

    Appearing on Good Morning America Monday, Trump's senior counselor Kellyanne Conway addressed the allegations . Trump provided no evidence for his claim.